网络棋牌

BJBAG2001#链脲佐菌素

编号:BJBAG2001
中文品名:链脲佐菌素 、链脲霉素 
英文名称:Streptozocin 
≥75% α-anomer basis, ≥98% (HPLC), powder 
CAS号 18883-66-4 
经验分子式(希尔表示法) C8H15N3O7 
网络棋牌 分子量 265.22 

 

  • 技术说明书
     

 

JIBENXINXI

性质

网络棋牌Related Categories

网络棋牌Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics,

网络棋牌Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, YIYANGHUADANDAIXIE, YIYANGHUADANHEXIBAOYINGJI, KANGSHENGSU, SHENGHUASHIJI, SHENGWUHUOXINGXIAOFENZI, XIBAOXINHAOZHUANDAOHESHENJINGKEXUE, XIBAOSHENGWUXUE, MEI、YIZHIJIHEDIWU

GENGDUO...

InChI Key  

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

assay  

≥75% α-anomer basis

 

网络棋牌≥98% (HPLC)

form  

powder

网络棋牌color  

white to light yellow

mp  

网络棋牌121 °C (dec.) (lit.)

Mode of action  

DNA synthesis | interferes

antibiotic activity spectrum  

neoplastics

网络棋牌originator  

Pfizer

storage temp.  

网络棋牌−20°C

 

产品描述

链脲佐菌素或链脲佐菌素是从不产色链霉菌中获得的。链脲佐菌素是一种葡糖胺-亚硝基脲,是一种仅通过GLUT2葡萄糖转运蛋白进入细胞的DNA烷化剂。链脲菌素,一种致糖尿病剂,对于产生胰岛素的胰岛β-细胞具有特别的毒性。它对GLUT2阳性神经内分泌肿瘤细胞具有毒性。

链脲菌素或链脲佐菌素用于诱导糖尿病动物模型,该化合物可用于胰腺β细胞癌的治疗,本公司所提供产品,仅供动物使用。

可提供 100mg/500mg/1g三个包装规格产品。

网络棋牌YIZHONGZAIYIDAOZHONGKEZUOWEIYIYANGHUADANGONGTIDEHANN-YAXIAOJIHUAHEWU;YOUDAOYIDAOSUFENMIXIBAODESIWANG,CHANSHENGTANGNIAOBINGDONGWUMOXING。KEYOUDAORANSETIDUANLIEDEYOUXIAODNAJIAJIHUAJI。 DUIBIAODAGLUT2PUTAOTANGZHUANYUNDANBAIDESHENJINGNEIFENMIZHONGLIUXIBAOXIJUYOUXIBAODUXING。

JISHUGUIGESHUOMINGSHU

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

S0130 - Product Information Sheet (57 KB)

ANQUANXINXI

Danger

危害声明 

 

网络棋牌GERENFANGHUZHUANGBEI 

网络棋牌Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

WEIHAIMA (OUZHOU) 

T

FENGXIANSHENGMING (OUZHOU) 

45

ANQUANSHENGMING (OUZHOU) 

53-45

网络棋牌RIDADR 

网络棋牌UN 3077 9 / PGIII

WGKDEGUO 

3

RTECS 

LZ5775000

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?

网络棋牌If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

网络棋牌How should I store Product S0130, Streptozocin, upon receipt?

网络棋牌Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.

How do I store solutions of Product S0130, Streptozocin?

Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.

网络棋牌What is the half-life of Product S0130, Streptozocin?

网络棋牌Streptozocin has a reported half life of 15 to 30 minutes.

网络棋牌How can I make a solution of Product S0130, Streptozocin?

网络棋牌This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.

CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?

We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).

网络棋牌How do I get lot-specific information or a Certificate of Analysis?

The lot specific COA document can be found by entering the lot number above under the "Documents" section.

网络棋牌How do I find price and availability?

网络棋牌There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.

网络棋牌What is the Department of Transportation shipping information for this product?

Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

My question is not addressed here, how can I contact Technical Service for assistance?

网络棋牌Ask a Scientist here.

SHIYANBUZHOUYUWENZHANG

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Did you use this product in your Paper? If so click here.

网络棋牌The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)

Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)

Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? Marco Analytical Biochemistry 504, 38-40, (2016)

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read abstract

网络棋牌Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.

Patrick Reeson et. al
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), undefined (2015-4-4)

Diabetes is a common comorbidity in stroke patients and a strong predictor of poor functional outcome. To provide a more mechanistic understanding of this clinically relevant problem, we focused on how diabetes affects blood-brain barrier (BBB) funct...

 

网络棋牌Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.

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Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.

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also commonly purchased with this product

     HUOHAO #

网络棋牌  SHANGPINMINGCHENG   

   级别       规格    价格   

  BJBAG2002  

  NINGMENGSUAN

    AR

  10g/瓶      10元  
  BJBAG2003   柠檬酸钠     AR   10g/瓶     10元  
  BJBAG2004   二甲双胍    原料药   25g/瓶      65元  

JISHUZHICHI:

WOMENDEZHUANJIATUANDUIZAISHENGMINGKEXUE、CAILIAOKEXUE、HUAXUEHECHENG、SEPU、FENXIYIJIQITAGEZHONGYANJIULINGYUDOUYONGYOUFENGFUDEJINGYAN。

 

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