≥75% α-anomer basis, ≥98% (HPLC), powder
网络棋牌 分子量 265.22
网络棋牌Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antibiotics by Mechanism of Action, Antineoplastic and Immunosuppressive Antibiotics,
网络棋牌Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cell Signaling Enzymes, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, Interferes with DNA Synthesis, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Pfizer Compounds, S, YIYANGHUADANDAIXIE, YIYANGHUADANHEXIBAOYINGJI, KANGSHENGSU, SHENGHUASHIJI, SHENGWUHUOXINGXIAOFENZI, XIBAOXINHAOZHUANDAOHESHENJINGKEXUE, XIBAOSHENGWUXUE, MEI、YIZHIJIHEDIWU
≥75% α-anomer basis
white to light yellow
网络棋牌121 °C (dec.) (lit.)
Mode of action
DNA synthesis | interferes
antibiotic activity spectrum
FT-IR Condensed Phase
S0130 - Product Information Sheet (57 KB)
网络棋牌Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
网络棋牌UN 3077 9 / PGIII
Frequently Asked Questions
Which document(s) contains shelf-life or expiration date information for a given product?
网络棋牌If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
网络棋牌How should I store Product S0130, Streptozocin, upon receipt?
网络棋牌Streptozocin should be stored at -20 degrees C with desiccation. The desiccant is to prevent moisture uptake which can shorten shelf-life.
How do I store solutions of Product S0130, Streptozocin?
Aqueous solutions rapidly undergo mutarotation to an equilibrium mixture of alpha- and beta-anomers. Maximum solution stability is at pH 4, with stability decreasing rapidly at higher or lower pH. Freshly prepared solutions are clear and have a light straw color. On standing, they take on a yellow to brown color and effervesce, indicating decomposition. Solutions should be prepared just before use, since the product is unstable.
网络棋牌What is the half-life of Product S0130, Streptozocin?
网络棋牌Streptozocin has a reported half life of 15 to 30 minutes.
网络棋牌How can I make a solution of Product S0130, Streptozocin?
网络棋牌This product dissolves in water at 50 mg/mL to give a light yellow solution, from clear to slightly hazy. We recommend using a 20 mM citrate buffer at pH 4.5 for best solution stability.
CanProduct S0130, Streptozocin, be used to induce diabetes? What concentration should be used?
We do not test Streptozocin, Product No. S0130 for biological activity.We recommend screening lots for biological activity.An intravenous injection of streptozocin into rats at a dose of 65 mg/kg body weight to induce diabetes has been reported by Burcelin R. et al. in Biochem. J., 291, 109-113 (1993).
网络棋牌How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
网络棋牌How do I find price and availability?
网络棋牌There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
网络棋牌What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
网络棋牌Ask a Scientist here.
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Did you use this product in your Paper? If so click here.
网络棋牌The Streptozotocin-Induced Diabetic Nude Mouse Model: Differences between Animals from Different Sources Melanie L Graham Comparative Medicine 61(4), 356-360, (2011)
Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans Chinedum Journal of diabetes and metabolic disorders 12, 60-60, (2013)
Housekeeping proteins: How useful are they in skeletal muscle diabetes studies and muscle hypertrophy models? Marco Analytical Biochemistry 504, 38-40, (2016)
网络棋牌Acute stimulation of brain mu opioid receptors inhibits glucosestimulated insulin secretion via sympathetic innervation Eva Tuduri Neuropharmacology 110, 322-332, (2016)
Cordyceps militaris Treatment Preserves Renal Function in Type 2 Diabetic Nephropathy Mice Sung-Hsun Yu PLoS ONE , -, (2016)
网络棋牌Delayed inhibition of VEGF signaling after stroke attenuates blood-brain barrier breakdown and improves functional recovery in a comorbidity-dependent manner.
Patrick Reeson et. al
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), undefined (2015-4-4)
Diabetes is a common comorbidity in stroke patients and a strong predictor of poor functional outcome. To provide a more mechanistic understanding of this clinically relevant problem, we focused on how diabetes affects blood-brain barrier (BBB) funct...
网络棋牌Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Keith Al-Hasani et. al
网络棋牌 Developmental cell, 26(1), undefined (2013-7-3)
网络棋牌It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether α cells in adult mice d...
Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.
Jayasankar Kosaraju et. al
Neuropharmacology, 72, undefined (2013-4-23)
Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacologica...
网络棋牌Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes.
Greg Tesch et. al
Diabetologia, 57(9), undefined (2014-6-25)
网络棋牌The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether deletion o...
Periostin induces pancreatic regeneration.
Johnathan K Smid et. al
Endocrinology, 156(3), undefined (2014-12-9)
We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes. Importantly, after partial pancreatectomy, Postn-deficient mice exhibit imp..
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